Open access
Sep 2026
Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis
It is demonstrated that SF3B1 undergoes intrinsic, IDR‐driven liquid‐liquid phase separation both in vitro and in vivo, forming nuclear condensates in oocytes and early embryos, which is essential for successful development to the blastocyst stage.
Kang Zhao, Ting-Yu Han, Yan-Li Cheng et al.
· Advancement of science · 0 citations