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Open access Sep 2026

Structure-Based Screening Identifies Polyphenol Glucuronides as Cyclophilin D Ligands

(1) Background: The mitochondrial permeability transition pore (mPTP) contributes to mitochondrial dysfunction under pathological conditions. Cyclophilin D (CypD), a key regulator of sustained mPTP opening, represents an important molecular target. However, systematic strategies for selecting an appropriate CypD crysta...

An-Nan Wu, Jie Zhang, Jing Zhao · 0 citations

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