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BmSNX20 is identified as a novel antiviral factor in silkworms and highlighted its role in linking membrane trafficking to autophagy and innate immunity, and novel insights into host-virus interactions in invertebrates are provided.
Bombyx mori cytoplasmic polyhedrosis virus (BmCPV), a double-stranded RNA reovirus, causes significant losses in sericulture; however, the host factors that support its replication remain poorly understood. Here, we identify Tudor staphylococcal nuclease (TSN) as a critical pro-viral host factor in silkworms. TSN is a...
Results identify BmLEB3 as a virus-responsive AMP and suggest that its expression is modulated by IMD-associated signalling and hormonal cues during BmCPV infection in B. mori.
Findings identify BmRPL11 as an antiviral factor in silkworms, potentially acting through an apoptotic rather than an autophagic pathway.
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