Open access
Jul 2026
Dual-Target Inhibition of CDK5 and PBK in Pituitary Neuroendocrine Tumors: Mechanisms and Therapeutic Potential
The CDK5-PBK mutual phosphorylation axis serves as a key driver of invasiveness in PitNETs and proguanil hydrochloride represents a promising candidate dual-target therapeutic agent capable of disrupting this pathway to suppress tumor growth.
Jinghao Jin, Zhaoyi Yi, Hong-Yun Wang et al.
· Genes · 0 citations