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Author

Jingjing Chen

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Open access Aug 2026

TDP-43 drives ferroptosis evasion by modulating PCBP1/PCBP2 axis to promote lung adenocarcinoma growth

It is reported that TDP-43 acts as a key ferroptosis regulator facilitating LUAD growth, and whole transcriptome sequencing combined with subsequent validation assays revealed that TDP-43 is capable of suppressing ferroptosis in LUAD cells.

Bo-Wen Liu, Xin Chen, Jingjing Chen et al. · 0 citations
Open access Aug 2026

Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders

LD5095 demonstrates potent and selective RIPK1 degradation across cell lines, with rapid kinetics and sustained degradation over 72h post-washout, and exhibited favorable pharmacokinetics, including metabolic stability and an extended half-life.

Dong Lu, Xin Yu, Han-Qing Lin et al. · 1 citation

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