Author

Jingjing Guo

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Review Open access Jul 2026

Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.

It is argued that epigenetic editing is progressively establishing itself as a distinctive therapeutic modality characterized by durable efficacy and sequence-independent safety-reversibility as a theoretical safety mechanism has been validated preclinically, but the monitoring and intervention infrastructure required for its clinical implementation remains to be established.

Shiqi Chang, Di Lu, Yuyuan Jin et al. · Clinical Epigenetics · 0 citations

Open access Jul 2026

Multi-level precise regulation of gene transcription in the yeast Saccharomyces cerevisiae based on light-sensitive CRISPR/Cas systems

The gene regulatory approaches at the translational and post-translational levels were integrated with optogenetic control patterns to attain very sensitive multi-level precision regulation of the dCas9 protein, thereby facilitating flexible regulation of transcription levels of target genes.

Yaokun Liang, Xianghui Qi, Song Gao et al. · Nucleic Acids Research · 0 citations