Sep 2026
SIK3-mKO Enhances Myelin Debris Phagocytosis via CD11c Complement Pathway for White Matter Protection Poststroke.
BACKGROUND White matter preservation is a rate-limiting factor in neurological recovery after ischemic stroke and depends on efficient clearance of myelin debris by microglia/macrophages. Our prior work demonstrated that microglia/macrophage-specific SIK3 (salt-inducible kinase) knockout (SIK3-mKO) promotes an anti-inf...
Lei-Lei Mao, Chen-Ran Wang, Ke Wang et al.
· Stroke · 0 citations