Rationale [18F]meta-fluorobenzylguanidine ([18F]MFBG) is an human norepinephrine transporter (hNET)-targeted PET tracer that has shown superior lesion detection than [123I]MIBG SPECT in patients with relapsed or refractory neuroblastoma. Its value in newly diagnosed patients, however, has not been well established. We...
Li-Feng Zhang, Xin-Hui Su, Xin-Yue Zheng et al.· Theranostics· 0 citations
Rapid radiopharmaceutical clearance limits the efficacy of peptide receptor radionuclide therapy (PRRT) for the treatment of advanced neuroendocrine tumors (NETs). In this prospective, single-center, single-arm, investigator-initiated trial, we evaluated the safety and efficacy of 177Lu-LNC1010-an optimized, long-actin...
Wei Guo, Chun-Lei Fan, Yu-Hang Chen et al.· Journal of Nuclear Medicine· 0 citations
The core biological functions of FAP-expressing fibroblasts in disease pathogenesis are delineated, and the rapid advancement of radionuclide-labeled FAPIs are systematically examined, including optimization of linkers, chelators, and albumin-binding moieties, along with multimerization strategies, which significantly...
Jie Liu, Xinzhi Zhao, Pei-Fei Liu et al.· Accounts of Chemical Researc...· 0 citations
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