Aug 2026
Post-translational chemical modification of E3 ligase for efficient target protein degradation.
This work reports the first ligand-directed chemical strategy that converts transient PROTAC-mediated ternary complex formation into binary target recognition via post-translational chemical modification of an E3 ligase, and believes it could provide a platform for next-generation targeted protein degraders to overcome the current limitation of PROTAC approach.
Eunbin Park, Jinjoo Jung, Gangasani Jagadeesh Kumar et al.
· Bioorganic chemistry (Print) · 0 citations