Review
Open access
Jul 2026
Engineering CAR-T cells for solid tumors: overcoming antigenic, trafficking, and microenvironmental barriers
Next-generation engineering strategies are being designed to overcome the obstacles that constrain CAR-T-cell efficacy in solid tumors and to guide the development of safer and more effective therapeutic platforms.
Ziyan Kong, Jinke Wang
· Frontiers in Immunology · 0 citations