Author

Jinmin Zhao

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Open access Sep 2026

The marine drug plitidepsin alleviates osteoporosis in estrogen-deficient mice by suppressing ROS-mediated NRF2/HO-1 signaling and osteoclast formation

Marine-derived compounds represent an important source of innovative therapeutics owing to their structural diversity and broad bioactivity; however, their potential in osteoporosis therapy remains insufficiently explored. This study investigated the effects of plitidepsin (Pli), a marine-origin cyclic peptide, on os...

Jin-Deng Liao, Liang Liao, Qiu-Fei Li et al. · Scientific Reports · 0 citations

Sep 2026

Cyclovirobuxine Prevents Osteoclastogenesis and Estrogen Deficiency-Induced Bone Loss by Inhibiting ROS Generation via the PI3K/AKT/FOXO1 Pathway

The results suggest that CVB suppresses osteoclastogenesis and their resorptive function through modulation of MAPK and PI3K/AKT/FOXO1 pathways and by enhancing antioxidant defense, which has potential therapeutic value for antiosteoporosis treatment.

Qiu-Fei Li, Na Hai, Jin-Deng Liao et al. · Journal of Agricultural and... · 0 citations

Open access Jul 2026

NIR-II-activated supramolecular LDH nanoarchitecture integrated with 3D-printed bioactive glass for hypoxia-resistant photodynamic osteosarcoma therapy and bone regeneration

A novel functionalized 3D-printed scaffold with NIR-II responsiveness (BGS/I-LDH@MgO2), designed to simultaneously address the dual needs of inhibiting osteosarcoma recurrence and promoting bone regeneration, demonstrates excellent anti-tumor and osteogenic properties.

Hong Cheng, Tao Wang, Hanji Huang et al. · Bioactive Materials · 0 citations