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Review Oct 2026

From Structural Modification to Diverse Pharmacological Activities: Recent Advances and Future Perspectives of Bile Acids.

Bile acids (BAs) are amphiphilic steroid acids that exert a broad range of physiological effects-including the regulation of metabolism, immune responses, and inflammatory processes-through activation of specific receptors such as the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5). The...

Hong-Xia Zhu, He-Ming Chen, Qing-Jun Gong et al. · 0 citations
Review Jul 2026

From Structure to Selectivity: Integrating CADD and AIDD in Rational Medicinal Chemistry Strategies for DYRK1A Inhibitor Discovery.

Dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a member of the CMGC kinase family, regulates diverse cellular processes and is implicated in Alzheimer's disease, Down syndrome, cancer, and diabetes. However, the clinical translation of DYRK1A inhibitors remains challenging due to limited select...

Minghui Yu, Shuangtian Tang, Lijuan Huang et al. · 0 citations

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