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Jinzhong Lin

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Open access Sep 2026

NAT10 governs development through the Xrp1-mediated stress response rather than its RNA acetylation activity

N4-acetylcytidine (ac4C) is installed by N-acetyltransferase 10 (NAT10) and represents the only known acetylation mark on messenger RNA. Since NAT10 also acetylates transfer RNA, ribosomal RNA (rRNA), and proteins, its in vivo molecular mechanisms remain elusive. Here, we demonstrate that knockdown of Drosophila NAT10...

Lin Wang, Zhao Xue, Shu-Yang Gao et al. · 0 citations
Open access Jul 2026

Rational and computation-assisted engineering of a compact and efficient StaCas9 genome editor

Natural variation in PAM recognition among SaCas9 orthologs is analyzed and StaCas9 is identified as a compact and efficient nuclease recognizing an NNG PAM, establishing StaCas9 as a high-performance genome-editing tool for therapeutic applications.

Miao-Miao Li, Wenni You, Yuwen Tian et al. · 1 citation

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