Safety, Immunogenicity, and Broad-Spectrum Protective Efficacy of a Naturally Attenuated GCRV-II Strain Against Viral and Bacterial Challenges in Grass Carp.
Grass carp hemorrhagic disease (GCHD), caused by genotype II grass carp reovirus (GCRV-II), is a severe viral disease affecting Chinese aquaculture. In this study, a naturally attenuated GCRV-II strain, GCRV-GD2021, was isolated from healthy grass carp and evaluated as a live-attenuated vaccine candidate. The virus was...