Jul 2026
Microbial Synthesis of Daphnetin by Engineering 2-Oxoglutarate-Dependent Dioxygenases.
Daphnetin is a clinically established coumarin, but its native biosynthetic pathway remains elusive. In this study, a 2-oxoglutarate-dependent dioxygenase (2OGD), AtS8H, was identified that hydroxylates umbelliferone (UMB) to daphnetin , enabling the design of an artificial biosynthetic pathway. However, the pathway ef...
Shunmin Ji, Chong Xie, Yanyan Wang et al.
· ACS Synthetic Biology · 0 citations