Open access
Sep 2026
Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain.
A single-cell atlas of APA of the aged human brain across 2 million cells from 379 human postmortem brains is reported to provide a cell-type-specific foundation to interrogate the cis and trans regulation of APA and to understand the contribution to disease heritability of this key post-transcriptional layer.
Jiu-Hong Nan, Carles A. Boix, Shao-Hui Shi et al.
· Nature Genetics · 0 citations