Author

Jixiang Sun

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Open access Aug 2026

Activating Sigma1R by fluoxetine suppresses neuronal ferroptosis in epilepsy by inhibiting MDM2-mediated GPX4 ubiquitination.

This study demonstrates that FLX provides neuroprotective and cognitive benefits in murine epilepsy models by inhibiting neuronal ferroptosis, highlighting its therapeutic potential for epilepsy and other ferroptosis-related neurological disorders.

Yuxiang Li, Cong Wang, Meng-Ying Huang et al. · Journal of Advanced Research · 0 citations