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Jocelyn Solorza

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Sep 2026

Multiscale Modeling of Icilin and Calcium Binding to Human TRPM8 Ion Channel: Insights From MD, MMPBSA, and QM/MM Analyses.

The transient receptor potential melastatin 8 (TRPM8) channel has been established as the principal molecular sensor of cold in mammals and has emerged as a promising pharmacological target for pain therapy. Whereas menthol activates TRPM8 independently of intracellular Ca2+, the synthetic agonist icilin strictly requi...

Jocelyn Solorza, Jans H. Alzate-Morales, Janin Riedelsberger et al. · 0 citations

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