Author

Jochen H. Weishaupt

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Open access Oct 2026

EARLY-ALS: a multicentre study on prodromal amyotrophic lateral sclerosis.

BACKGROUND Neurodegenerative diseases often feature a prolonged phase of subtle changes preceding diagnosis. In amyotrophic lateral sclerosis (ALS), defining this prodromal period is critical for identifying early disease features and intervention windows. METHODS In this case-control study, 475 patients with ALS and...

I. Cordts, A. Galhoz, L. Tzeplaeff et al. · EBioMedicine · 0 citations

Review Open access Oct 2026

Update on somatic mutations in major neurodegenerative diseases: mutational signatures in neurons and mosaicism.

Somatic mutations in major neurodegenerative diseases are poorly understood, but research over the past 2 years provides valuable insights. Single-cell whole-genome sequencing of vulnerable neurons in Alzheimer's disease and amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) revealed excess accumulation of...

A. Freischmidt, Jochen H. Weishaupt · Current Opinion in Genetics... · 0 citations