Open access
Jul 2026
DESIGN, SYNTHESIS, AND IN VITRO SCREENING OF MACROCYCLIC UREA-BASED HETEROCYCLIC SYSTEMS WITH UNUSUAL RING CONSTRAINTS
The rational design, synthesis, and comprehensive biological evaluation of a novel class of macrocyclic ureas that incorporate an unusual sp3-rich constraint are reported, providing a validated, highly translatable blueprint for successfully leveraging unusual structural constraints to discover potent, orally bioavaila...
Pradeep Kumar Mr, Palati Divya Jyothi, G. Hemalatha et al.
· Genetics and Molecular Resea... · 0 citations