Author

Johanna Klughammer

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Open access Aug 2026

Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-κB

These findings establish RELA haploinsufficiency as a cause of systemic immune dysregulation and link defective NF-κB feedback control to unchecked inflammation and inflammatory cell death.

Nadja Lucas, S. Weidler, Antonia Eicher et al. · JCI Insight · 0 citations