Author

Johannes Broichhagen

3 papers indexed here

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Open access Sep 2026

Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins

Metabotropic glutamate receptors (mGluRs) are prototypical, dimeric family C G protein-coupled receptors (GPCR) that perform crucial modulatory roles throughout the nervous system. While mGluR activation and signaling through G proteins has been studied extensively, how these receptors interact with and are desensitize...

Dagan C. Marx, Kevin Huynh, Alberto J. Gonzalez-Hernandez et al. · Nature Communications · 1 citation

Open access Sep 2026

Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins

A single molecule pulldown (SiMPull) assay is developed that reports on both relative GPCR:β-arr interaction strength and stoichiometry to uncover molecular diversity in β-arr coupling to the neuromodulatory metabotropic glutamate receptors (mGluRs), prototypical, dimeric family C GPCRs.

Dagan C. Marx, Alberto J. Gonzalez-Hernandez, Joon Lee et al. · Nature Communications · 1 citation

Open access Aug 2026

Emergence of new function through evolutionary divergence of an intrinsically disordered region

These findings show how acquisition of transient secondary structure within an intrinsically disordered region can generate new molecular behaviors while preserving ancestral functions, providing a mechanism for the functional specialization of paralogous proteins.

Carlos A. Elena-Real, Antonia M. Körber, Blaise Gatin-Fraudet et al. · bioRxiv · 0 citations