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J. Michaelian

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Open access Oct 2026

Plasma metabolomic profiling of frailty in older adults at risk of dementia

Background: Frailty is a prominent risk factor for dementia. Early detection of at-risk individuals may enable intervention to prevent or slow dementia pathology. Blood-based biomarker discovery could offer a path for early detection of frailty and cognitive decline. Methods: Older adults at risk of dementia underwent...

I. Alldritt, J. Michaelian, R. Yu et al. · 0 citations
Open access Jul 2026

Predictive value of plasma p-tau217 for Alzheimer’s dementia compared to other blood-based biomarkers

P-tau217, NfL and GFAP showed strong associations with AD risk, especially within the first 9 years of follow-up, outperforming p-tau181, and over the later years of follow-up, the predictive accuracy of p-tau217 was significantly reduced.

K. Trares, D. Duman, L. Beyer et al. · 0 citations

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