Author

Johannes Morstein

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Open access Sep 2026

Chemical Genetic Targeting of the LRRK2 GTPase Domain

Genetic variants throughout the multi-domain protein leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant Parkinson’s disease, and the most prevalent Parkinson’s-associated LRRK2 variants enhance kinase activity. Hence, the kinase domain has been extensively targeted for therapeutic...

Rachel E. Prorok, Lawrence Y. Zhu, Vickie Bowcut et al. · bioRxiv · 0 citations