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Johannes Singer

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Open access Oct 2026

The tRNA-Modification Geranyl-2-Thiouridine Enables RNA-Lipid Association.

The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of a variety of lipids (including cationic) in high amounts to form complexes with the negatively charged RNA. While this approach was successful for t...

Johannes Singer, Kathrin Halter, Chun-Yin Chan et al. · 0 citations

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