Author

John C. Bowler

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Open access May 2025

Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex

Animals can solve new, complex tasks by reusing and adapting what they’ve learned before. This kind of flexibility depends not just on having prior experience, but on how that experience was structured in the first place. The design of early training curriculum is especially important: poorly structured experiences can...

John C. Bowler, D. Azhar, Cambria M. Jensen et al. · bioRxiv · 5 citations

Open access Sep 2026

Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex

RNNs are trained on an odor timing task used to study complex timing behavior in mice and then tested the model predictions with mouse behavior and medial entorhinal cortex recordings, demonstrating that the structure of prior experience governs how flexible, generalizable knowledge emerges in biological systems and co...

John C. Bowler, D. Azhar, Cambria M. Jensen et al. · Nature Neuroscience · 0 citations

Open access Jul 2026

Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex

It is found that spatial and temporal representations were partially overlapping but systematically biased across the MEC population, suggesting MEC is organized along a coding gradient, ranging from dedicated stable spatial coding neurons to more flexible spatial or temporal coding neurons which represent information...

Hyun-Woo Lee, John C. Bowler, James G. Heys · bioRxiv · 0 citations