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Author

John D. Clarke

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Open access Oct 2026

Mechanism of spike opening in a mammalian gammacoronavirus

Structural insights reveal conserved principles regulating spike dynamics across coronavirus genera and support lipid binding as a potential modulatory mechanism of spike opening.

John D. Clarke, Michalina Grabias, Antonio di Maio et al. · 0 citations
Open access Aug 2026

Nanobodies against the S2 region of the spike protein potently neutralize SARS-CoV-2 viruses and show resistance to viral immune escape

The results show the value of nanobody technology for identifying novel neutralising epitopes in the S2 region of beta-coronaviruses with potential for the development of new selective anti-viral agents.

John D. Clarke, Luke M. Jones, Imogen I. H. Buckle et al. · 0 citations

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