How inflammation shapes acute myeloid leukaemia (AML) has come under scrutiny, as it may explain the disease’s resistance to immunotherapy approaches. IFNγ has emerged as a key cytokine with paradoxical roles in suppressing and supporting AML growth, and the fundamental question of how leukemic stem cells (LSCs) respon...
C. Pospori, A. Donada, Helena Boutzen et al.· bioRxiv· 0 citations
Primitive hematopoietic stem cells (pHSCs) sustain lifelong hematopoiesis through tightly regulated transitions between quiescence and activation. Circadian oscillations influence hematopoiesis; however, the mechanisms coordinating metabolic state and stem cell function daily remain incompletely defined. Here, we show...
Priyasmita Chakrabarti, Abhishek K. Singh, Nicola K. Wilson et al.· Blood· 0 citations
Findings reveal CD59 as a critical regulator of Ras-MAPK signaling required for AML growth and nominate its rILYd4-mediated degradation as a therapeutic strategy.
Abdula Maher, Dhanoop Manikoth Ayyathan, S. Cathelin et al.· bioRxiv· 0 citations
This study provides direct evidence that VEXAS-specific TE govern HSC clonal dominance, thereby uncovering a regulatory axis underlying HSC biology and disease mechanisms, opening a therapeutic strategy directed towards the repetitive genome.
A. Varesi, Sontago Dong, Chiara Gaddoni et al.· bioRxiv· 0 citations
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