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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

John G. Doench

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2 papers indexed here

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Open access Sep 2026

Therapy-persistent leukemia is selectively vulnerable to SLC23A1 restoration via targeting KHSRP.

Acute myeloid leukemia (AML) is prone to relapse driven by therapy-persistent residual cells. To discover specific vulnerabilities in this population, we performed genome-wide CRISPR interference screens in leukemia cells treated with multiple agents. KHSRP was the top hit, whose depletion sensitized AML cells to thera...

Qing-Yu Luo, Karley S. Whalen, Xiao-Wei Wu et al. · 0 citations
Open access Oct 2026

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation.

Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained...

Marilou Tétard, Tian Lin, N. Peterson et al. · 0 citations

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