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John Jacob

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Review Open access Sep 2026

The Medulloblastoma Microenvironment: Developmental Niches, Cellular Crosstalk and Therapeutic Opportunities

Medulloblastoma is increasingly best understood not simply as a cell-autonomous embryonal tumour, but as a family of molecularly and anatomically distinct diseases shaped by the developing cerebellum and posterior fossa. The four principal molecular subgroups—WNT, sonic hedgehog, Group 3 and Group 4—differ not only in...

John Jacob · 0 citations

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