Author

John K. McCormick

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Review Open access Sep 2026

Mechanisms underlying rheumatic heart disease immune-mediated pathogenesis: T-cell responses, cytokine networks, and immune dysregulation as drivers of valvular injury.

Acute rheumatic fever is an immune-mediated sequela of Streptococcus pyogenes (group A Streptococcus) infection, presenting with fever, arthritis, chorea, rash, and, crucially, carditis. Without effective secondary prophylaxis and care, acute rheumatic fever can progress to chronic rheumatic heart disease, a leading ye...

Adrien Lupieri, Juan Manuel Díaz, T. B. Moreira et al. · The Lancet Microbe · 0 citations

Open access Aug 2026

The RND family efflux pump FemT contributes to lipid homeostasis in Staphylococcus aureus”

The constructed FemT exhibited impaired growth on exposure to saturated and unsaturated fatty acids, and exposure to subinhibitory 50 µM palmitic acid promoted accumulation of reactive oxygen species, reduced respiratory activity, and altered membrane function and morphology, consistent with a general role in efflux of...

A. Thukral, Camryn Bonn Dunbar, Jamie N Halucha et al. · bioRxiv · 0 citations