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John Kendrick

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Review Open access Sep 2026

Animal reuse in safety assessment studies: a review of current practices, challenges and 3Rs opportunities

Regulatory nonclinical safety assessment in animals remains an essential part of the drug development process. Historically, naive animals are used within most nonclinical studies to avoid confounding variables such as prior drug exposure. However, opportunities exist to advance the 3Rs (Replacement, Reduction and Refi...

John Kendrick, David Shaw, M. Jourdain et al. · 0 citations

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