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John M. Maris

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Open access Aug 2026

Surface and global proteomics identify ROR2 and other proteins as potentially actionable immunotherapeutic targets in osteosarcoma.

Osteosarcoma (OS) is the most common human primary bone cancer, primarily affecting children and young adults. While the survival rate of patients diagnosed with localized OS is ∼65%, this decreases to ∼20% for patients with metastatic disease, and recurrent disease remains largely incurable. Therefore, identifying new...

Brian Mooney, Xiaojie Chu, G. Negri et al. · 0 citations
Sep 2026

Abstract IA07: Strategies to eliminate drug tolerant neuroblastoma persister cells

High-risk neuroblastoma remains a leading cause of pediatric cancer mortality, and relapse—driven by chemotherapy-resistant "persister" tumor cells that survive induction therapy—accounts for the majority of these deaths. Our recent single-nucleus and whole-genome sequencing analysis of matched diagnosis and definiti...

John M. Maris · 0 citations
Open access Jul 2026

HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors 2258016

HLA-Shuttle restores antigen presentation in immunologically cold tumor cells, facilitating identification of TAAs with favorable therapeutic potential and identifying multiple novel tumor associated antigens (TAAs) from both known and novel cancer immunotherapy targets.

Daniel Hwang, Molly C. Erdman, Santosh Adhikari et al. · 0 citations

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