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Author

John M. Pleinis

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Open access Sep 2026

Cell volume regulation in metazoans involves phosphorylation of TSC22D proteins.

Intracellular water and ion homeostasis are fundamental determinants of cell volume and macromolecular crowding. WNK kinases are central sensors of osmotic stress, yet how their activity is spatiotemporally regulated remains unclear. Here, we identify that TSC22D and NRBP protein families are WNK-dependent substrates....

Seon-Yong Lee, Yu-Xi Xiao, Magali Aguilera-Uribe et al. · 0 citations

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