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Author

John M. Sedivy

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2 papers indexed here

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Open access Aug 2026

cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation

Aging-associated inflammation is a driver of multiple age-associated diseases. Cyclic GMP–AMP synthase (cGAS) contributes to inflammaging by responding to endogenously-derived cytoplasmic DNA in aged cells. Although cGAS-knockout (KO) mice are viable, their aging has not been characterized. Unexpectedly, we found that...

John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner et al. · 2 citations
Aug 2026

Optimized Reverse Transfection Protocol for Telomerase mRNA Delivery to Early-Senescent Human Fibroblasts.

This protocol describes an optimized reverse-transfection method for the efficient delivery of modified messenger RNA (mRNA) into senescent human fibroblasts and provides a practical approach for transient mRNA delivery into senescent cells.

Sukanta Jash, John M. Sedivy · 0 citations

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