Author

John P. Morrissey

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Open access Aug 2026

Reprogramming a Hgt-family Kluyveromyces marxianus sugar transporter by site-directed mutagenesis to enable co-consumption of glucose and xylose

This study provides the first example of engineering an Hgt-like transporter for altered sugar specificity, engineering the KMAR_10 531 N325V variant, which reduced glucose affinity ∼20-fold while improving xylose affinity more than three-fold.

Lorena Donzella, Carlos Belloch-Molina, John P. Morrissey et al. · FEMS Yeast Research · 1 citation

Review Open access Jul 2026

Converging quality by design, artificial intelligence, and biofoundry automation: A new paradigm for scalable circular biomanufacturing.

Synthetic biology applies engineering principles to the rational design of biological systems with the aim of producing predictable and tunable behaviour. Although the field's conceptual foundations and core technologies are well established, the recent simultaneous maturation of Quality by Design (QbD), artificial int...

Carlos Belloch-Molina, Francisco Vitor Santos da Silva, John P. Morrissey et al. · Biotechnology Advances · 0 citations