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John P. Whelchel

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Sep 2026

Abstract B121: Induction of Immunogenic Cell Death in Pancreatic Ductal Adenocarcinoma by a Sigma-2 Ligand–Conjugated xCT Inhibitor

Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal and is largely resistant to current immunotherapy approaches, in part because of a profoundly immunosuppressive tumor microenvironment (TME) that limits antigen presentation and effector immune cell activity. Immunogenic cell death (ICD) is a regulated...

David Barr, Shub Mehta, John P. Whelchel et al. · 0 citations

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