John Patani

Design of Stable Dual-Polymer Amorphous Solid Dispersions: Role of Thermodynamics and Kinetics

This dual-polymer approach provided a basis for designing amorphous solid dispersions with high drug loading and improved physical stability thanks to a synergistic mechanism where HPMCAS provided resistance to nucleation by increasing the activation energy barrier, while PVP/PVPVA kinetically lowered the attempt jump...