Author

John T. Murphy

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Open access Sep 2026

Impaired Proteostasis is an Early Feature of the Diabetic Heart in Humans and Mice

Diabetes and obesity increase cardiac lipid levels leading to cardiomyopathy and heart failure. We hypothesized that intermittent fasting would reduce cardiac lipid levels. Surprisingly, intermittent fasting increased myocardial triglyceride content, but rescued mortality and attenuated cardiomyopathy in mice overexpre...

David R. Rawnsley, Chen Zhao, Xiu-Cui Ma et al. · bioRxiv · 0 citations

Open access Aug 2026

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

Background: Protein quality control (PQC) is critical for maintaining sarcomere structure and function in cardiomyocytes. Mutations in PQC pathway proteins, namely CRYAB-R120G (arginine to glycine at position 120) and BAG3-P209L (proline to lysine at position 209) induce protein aggregates and cardiomyopathy in humans....

David R. Rawnsley, Moydul Islam, Chen Zhao et al. · Circulation Research · 0 citations