John T. Schiller

TGF-β-induced epithelial to mesenchymal transition drives proteoglycan binding specificity of HPV-based drug conjugates for cancer cells

Human papillomaviruses (HPVs) utilize specifically modified proteoglycans (PGs) within the basement membrane as attachment factors prior to cell entry and infection. Similarly modified PGs are also found on cancer cells, which enables HPV with tumor-selective binding properties and highlights the potential developm...