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Author

John W. Mellors

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Open access Aug 2026

Ultrasensitive single-genome sequencing reveals strong purifying selection in acute HIV-1 infection

It is found that the accumulation of mutations was slower than expected, implying a selection against HIV-1 diversification in acute infection, potentially leaving a window of low genetic diversity for the study of new interventions towards inducing viremic control, such as immunotherapy or mRNA vaccination.

A. Capoferri, V. Boltz, W. Shao et al. · 0 citations
Open access Aug 2026

Unique CD8+ T Cell Populations Expand during ART and Predict Delayed HIV-1 Rebound

A dynamic CD8+ T cell state continuum is identified as a central determinant of HIV-1 rebound, even in the absence of antigen-specificity, where ART establishes a predictive poised naïve state that can be further leveraged by vaccination to enhance protective stem-like memory responses.

Jie Wang, Gautam Kundu, P. Ehrenberg et al. · 0 citations

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