Simian Immunodeficiency virus/ Human Immunodeficiency virus induces arachidonic acid-mediated inflammation in the heart by a Pannexin-1 mechanism.
HIV-associated cardiovascular disease (HIV-CVD) is a major comorbidity in people living with HIV (PLWH), despite effective anti-retroviral therapy (ART). The mechanisms of HIV-CVD have been associated with inflammation, ART toxicity, residual viral replication, and the presence of viral reservoirs, but the data suggest...