Open access
Jul 2026
BxbI-mediated insertion of a 77kb human RET sensitive haplotype into the mouse genome to generate a humanized model of Hirschsprung disease
This study provides a robust framework for modeling human-specific regulatory disorders and demonstrates the critical impact of non-coding variation on disease pathogenesis.
Ryan D. Fine, B. Low, Jarod A. Rollins et al.
· bioRxiv · 0 citations