Open access
Sep 2026
MAPK signaling links BRD2 chromatin occupancy to PI3K/AKT inhibitor sensitivity
Bromodomain and extra-terminal (BET) proteins, BRD2, BRD3, BRD4, and BRDT, couple histone acetylation to transcription by recruiting elongation and transcription factor complexes to chromatin. Although BET proteins are promising therapeutic targets, the functions of individual family members remain incompletely underst...
Josefina Mendez, Simone Bruno, Alexandra Indeglia et al.
· bioRxiv · 0 citations