Author

Jonas B. Desjardins

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Open access Sep 2026

A type VI secretion ADP-ribosyltransferase Rhs toxin selectively modifies charged tRNAThr(GGU) anticodon loops to block ACC codon decoding

Abstract The type VI secretion system (T6SS) is a sophisticated machine that uses a contractile mechanism to deliver antibacterial toxins into neighboring cells, hence participating to interbacterial competition and pathogenesis. Here, we characterize the T6SS-associated rearrangement hotspot RhsF polymorphic toxin fro...

Maïalène Chabalier, Jonas B. Desjardins, J. Martinkus et al. · Nucleic Acids Research · 0 citations

Sep 2026

Experimental evolution reveals genetic routes for adaptive loss of the antibacterial type VI secretion system.

This work combined experimental evolution with whole-genome sequencing and whole-genome sequencing identified two RfaH-binding ops elements within the sci1 cluster, revealing antitermination as a regulatory element of EAEC T6SS transcription, which is conserved among Enterobacteriaceae.

Boris Taillefer, Jonas B. Desjardins, Eric Cascales · Current Biology · 0 citations