Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a clinically relevant subtype of fibrotic ILD. We compared baseline characteristics, treatment patterns, transplant-free survival (TFS) and progression-free survival (PFS) between CTD-ILD and non-CTD ILD.
In the prospective German IN...
J. Behr, F. Bonella, Andreas Günther et al.· ERJ Open Research· 0 citations
BOS engages structural-cell circuits largely shared with RAS and fibrotic lung diseases, but along an airway-centered rather than parenchyma-centered axis, and shared structural programs may therefore be targetable across CLAD phenotypes.
Jannik Ruwisch, Hande Yilmaz, Leonard Christian et al.· bioRxiv· 0 citations
A potential involvement of vascular remodelling in CLAD pathophysiology is suggested, with changes consistent with pro-inflammatory and fibrogenic processes in CD31+ regions.
Axelle Coppens, Rahel Bodenmann, Janik Riese et al.· American Journal of Transpla...· 1 citation
Considering the multifaceted differences of RAS and idiopathic pulmonary fibrosis, a surprising general principle of an entity-spanning composition of the fibrotic niche by aberrant basaloid cells localized at the fibrotic edge, ectopic COL15A1+ pVECs and CTHRC1+ fibrotic fibroblasts is revealed.
L. Leiber, Leonard Christian, L. Neubert et al.· European Respiratory Journal· 0 citations
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