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Jonatan Barrera-Chimal

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Open access Aug 2026

Matrix Gla Protein is a novel regulator of TGFβ–dependent fibroblast activation and kidney fibrosis

It is shown that MGP deficiency attenuates renal fibrosis, suppresses fibroblast activation, and preserves kidney function following folic acid nephropathy and unilateral ureteral obstruction, supporting MGP as a potential fibroblast-associated target for future strategies aimed at limiting CKD progression.

Jonatan Barrera-Chimal, J. López-Ramirez, Nathalie Henley et al. · 0 citations
Open access Aug 2026

SMOC2 promotes partial epithelial-mesenchymal transition and maladaptive repair in renal tubular epithelial cells

It is shown that SMOC2 localized to the basement membrane of injured TECs across 3 murine models of kidney injury and induced a partial epithelial-to-mesenchymal (EMT) transition in TECs, and its extracellular calcium-binding domain mediated binding to the decellularized extracellular matrix accounted for most of its e...

Schrodinger Cenatus, Peng Gao, Nathalie Henley et al. · 0 citations

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