Author

Jonathan A. Nowak

3 papers indexed here

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Open access Sep 2026

CD4 T cells convert transient responses to KRAS inhibition to durable remissions in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is refractory to most therapies, including immunotherapies, for which reinvigoration of CD8 T cells through immune checkpoint blockade is insufficient to induce long-term, durable remissions. Direct KRAS inhibitors (KRASi) have shown clinical promise, although acquired resistance...

Li Qiang, Megan T. Hoffman, Jung-Ho Chun et al. · Cell · 0 citations

Sep 2026

Abstract PR006: A time-to-event model for pancreatic cancer risk prediction across multiple future intervals using longitudinal structured electronic health records

To facilitate risk assessment for pancreatic ductal adenocarcinoma (PDAC) in the general population, we developed time-to-event models using longitudinal structured electronic health record (EHR) data to estimate 6–12, 12–24, and 24–36 months PDAC risk. The model was developed using UK Biobank (UKB), a lar...

Ji-Fan Gao, Mina Stanikic, Eshna Lahr et al. · Cancer Research · 0 citations

Review Sep 2026

Abstract A091: Single-cell spatial transcriptomics reveals reprograming molecular hallmarks of PanIN initiation and progression preceding histological changes

Recent studies have identified a high prevalence of low grade pancreatic intraepithelial neoplasia (PanIN) in the pancreata of healthy adults. This study aimed to characterize the transcriptomic landscape of human PanINs at single cell resolution, with the goal of identifying hallmarks of initiation and progressi...

C. Nguyen, Anders W. Ohman, Winston R. Becker et al. · Cancer Research · 0 citations