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Jonathan B. Demb

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Open access Aug 2026

Reprogramming lineage-traced Müller glia for robust proliferation and neurogenesis in adult mammalian retinas.

The therapeutic potential of adeno-associated virus (AAV)-mediated one-step glia-to-neuron conversion has been challenged following rigorous lineage-tracing analyses. In zebrafish, Müller glia (MG) serve as retinal stem cells to replenish lost neurons after injury. In contrast, mammalian MG do not spontaneously re-ente...

Ye Xie, Ying Xin, Thomas E. Zapadka et al. · 0 citations

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