Author

Jonathan K. Watts

2 papers indexed here

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Review Open access Sep 2026

Nucleic acid therapeutics in neurodegenerative disorders: emerging technologies and clinical landscape

This review summarizes three major NAT platforms—antisense oligonucleotides, small interfering RNAs, and aptamers—by highlighting their mechanisms of action, design principles to enhance their biodistribution, durability, and safety, and emerging novel delivery strategies for CNS targeting.

Masahiro Ohara, S. Ishigaki, Jonathan K. Watts et al. · Molecular Neurodegeneration... · 0 citations

Open access Aug 2026

Improved Purification of sgRNA and pegRNA by Use of a 5’-Terminal Dioctyloxytrityl (DOT) Protecting Group

DOT chemistry is analogous to “DMT-ON” approaches that are well known and widely used in the field, and is fully compatible with existing synthesis workflows, but dramatically improves HPLC purification relative to DMT-ON approaches by providing higher retention and thus better resolution to enable the purification of...

Atish Wagh, Jonathan K. Watts · Journal of Organic Chemistry · 0 citations